Juliana Ramos Chaves a, b, c, d; Carol Rosal c; Antonio Modesto c; Eliel Barbosa c; Jonathan Souza Sarraf a, d; Thaís Suellen Ramos Allen a, e; Taissa Thomaz c; André Salim Khayat c, f
a Oncológica do Brasil - Ensino e Pesquisa [Teaching and Research]; b Brazilian Navy; c Hospital Universitário João de Barros Barreto (HUJBB) – Núcleo de Pesquisa em Oncologia (NPO); d Postgraduate course in Molecular Genetics and Biology - Universidade Federal do Pará (UFPA); e Universidade do Estado do Pará (UEPA); f Universidade Federal do Pará (UFPA)
It is known that abnormal expression of miRNAs in the gastric cancer (GC) contributes to its carcinogenesis. Therefore, ingestion of commercial (usual) water on a daily basis may be a contributing factor for the occurrence of alterations in the gastric mucosal. In this study, it was evaluated the expression of the miRNAs miR-29c, miR-7, miR-155, and miR-135b in the gastric tissue of patients with gastritis before and after the consumption of alkaline water (pH range from 8.0 to 10.0), as well as the clinic pathological characteristics.
50 subjects from the Amazon region, diagnosed with gastritis that routinely used commercial (usual)water with a pH lower than 5.0, were enrolled to change the consume water to a pH of 8.5 to 10.0 for 5months.
Endoscopic findings of gastritis were such different (less severe disease), p = 0.024; in 43% diagnosed with moderate gastritis upfront esophagogastroduodenoscopy (EGD) presented mild gastritis after the consumption of alkaline water, according to study methods; there were no worsening gastritis and there were a significant increase in the expression of miR-135b (p = 0.039) and miR-29c (p = 0.039).
Modified pH range water (from 8.0 to 10.0) ingested for 5 months was able lead to a less severe gastritis according to the Sidney classification system, suggesting that this lifestyle change represented a clinical benefit in patients with gastritis on the Amazon region. In addition, higher expression of miR-135b and miR-29c was observed after the consumption of alkaline water for 5 months.
Evaluation of the Sidney classification between endoscopies in patients with gastritis in Belém,Pará.